CME Activity Description

Expert Series

Practical Soft Tissue Pathology: A Comprehensive and Contemporary Update

Jason L. Hornick, M.D., Ph.D. Expert Series – Practical Soft Tissue Pathology: A Comprehensive and Contemporary Update This accredited Continuing Medical Education (CME) activity provides a comprehensive and practical update in soft tissue pathology, with a strong emphasis on a pattern-based diagnostic approach and real-world sign-out challenges encountered in daily practice.

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Target Audience

This program is primarily designed for:

• Practicing pathologists

• Surgical pathologists

• Pathologists with a special interest in soft tissue tumors and sarcoma diagnostics

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Educational Objectives

Upon completion of this CME activity, participants will be able to:

• Apply a pattern-based approach to the differential diagnosis of soft tissue tumors

• Discuss the differential diagnosis of cutaneous mesenchymal tumors

• Describe the key histologic features of pleomorphic soft tissue tumors

• Recognize histologic and genetic subtypes of gastrointestinal stromal tumors (GIST)

• Apply a pattern-based diagnostic approach to vascular and nerve sheath tumors

• Utilize immunohistochemistry effectively in the diagnosis of soft tissue tumors

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Educational Preparation

No special educational preparation is required for participation in this CME activity.

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Faculty

Jason L. Hornick, M.D., Ph.D.
Director of Surgical Pathology and Immunohistochemistry
Brigham and Women’s Hospital
Professor of Pathology
Harvard Medical School
Boston, Massachusetts

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Course Content / Lecture Titles

Core Foundations

1. Introduction to Soft Tissue Pathology: The New 2026 WHO Classification, Grading, and a Pattern-Based Approach

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Pattern-Based Diagnostic Categories

2. Spindle Cell Tumors of Adults, Part I: Differential Diagnosis and Best Markers

3. Spindle Cell Tumors of Adults, Part II: Differential Diagnosis and Best Markers

4. Round Cell Sarcomas: Histologic Clues and Ancillary Testing

5. Pleomorphic Sarcomas: It Is Easier Than You Think!

6. Myxoid Tumors of Skin and Soft Tissue: From Benign to Malignant

7. Epithelioid Tumors: Diagnostic Challenges and How to Prevent Disaster

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Site-Specific and Lineage-Based Tumors

8. Cutaneous Mesenchymal Tumors: What’s New?

9. Gastrointestinal Mesenchymal Tumors: What Do We Need to Know?

10. Vascular Tumors: Vasformative and Not So Much

11. Nerve Sheath Tumors: Key Features and Problems

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Regional Pathology

12. Mesenchymal Tumors of the Head and Neck: Clues and Pitfalls

13. Mesenchymal Tumors of the Head and Neck: Clues and Pitfalls (Advanced / Extended Session)