Cleveland Clinic Multispecialty Pathology 2026

Expert Pathology for Everyday Cases

Through engaging, case-based instruction, the Cleveland Clinic Multispecialty Pathology online video CME program delivers practical solutions that will help you tackle the real-world diagnostic challenges you see every day.

This continuing medical education program features renowned subspecialists who share the tips they use at the microscope, helping you strengthen diagnostic accuracy, build confidence, and enhance patient care — without unnecessary focus on esoterica. You’ll gain immediately useful insights from high-yield topics across multiple organ systems, including:

• Prostate cancer grading and genitourinary pathology essentials
• Thoracic pathology and high-value immunostains
• Liver, pancreas, and gastrointestinal diagnostic challenges
• Breast pathology, including lobular and triple-negative tumors
• Gynecologic pathology updates and emerging entities

Date of Original Release: March 31, 2026

Estimated Time to Complete: 14.75 hours

Learning Objectives

At the conclusion of this activity, the participant will be able to:

• Review neuroendocrine neoplasia of the gastrointestinal tract and pancreas
• Accurately grade prostate cancer
• Review endometrial carcinoma, including old and new entities
• Discuss helpful immunohistochemical markers in thoracic pathology
• Distinguish between lobular breast carcinoma and its mimics

Intended Audience

This activity is designed for pathologists, pathology residents, and fellows.

+ Topics:

• Prostate Cancer Grading: The Cleveland Clinic Approach – Sean Williamson, MD
• Six Diagnoses to Know in Genitourinary Pathology – Sean Williamson, MD
• Six Really Helpful Immunostains That Help Me to Clinch Diagnoses in Thoracic Consults – Sanjay Mukhopadhyay, MD
• Mediastinal Pathology – Thymoma and Beyond – Sanjay Mukhopadhyay, MD
• Diagnosis and Reporting of Steatotic Liver Disease – Jacob Sweeney, MD
• Beyond Acute Appendicitis – Important Diagnoses in Appendectomy Specimens – Jacob Sweeney, MD
• Lobular Lesions – A Look at Their Many Looks – Raza Hoda, MD
• Triple-Negative Breast Carcinomas – Rare Favorable Subtypes and Diagnostic Challenges – Raza Hoda, MD
• Endometrial Carcinomas – Old and New Entities That Should Not Be Missed – Karuna Garg, MD
• Uterine Mesenchymal Neoplasms – Some Old and Some New – Karuna Garg, MD
• Mesothelioma vs Its Differentials – Which Immunostains are Most Helpful in 2026 – Sanjay Mukhopadhyay, MD
• Twelve Diagnoses in Thoracic Pathology You Can Make on H and E – Sanjay Mukhopadhyay, MD
• Mesenchymal Tumors of the Genitourinary Tract – Sean Williamson, MD
• Morphologic-Molecular Correlates in Genitourinary Pathology – Sean Williamson, MD
• Neuroendocrine Neoplasia of the Gastrointestinal Tract and Pancreas – Diagnosis and Pitfalls – Jacob Sweeney, MD
• Common Questions in Frozen Section Pathology of the Liver and Pancreas – Jacob Sweeney, MD
• Classification of Vulvar Squamous Neoplasia – Updates and Current Practice – Karuna Garg, MD
• Ovarian Mucinous Neoplasms – Common Diagnostic Dilemmas – Karuna Garg, MD
• Papillary Breast Tumors – Review of Common, Uncommon, and Unexpected Variants – Raza Hoda, MD
• Beyond Metaplastic – Spectrum of Spindle Cell Lesions of Breast – Raza Hoda, MD